Conservation Medicine and more recently One Health have emphasized the need to bridge disciplines, thereby linking human health, animal health, and ecosystem health under the paradigm “health connects all species in the planet”. Transdisciplinarity, integrative research, and capacity building are core elements in establishing interventions that address extant, emerging, and re-emerging pathogens and toxicants that harm humans, wildlife, and other components of biodiversity.  Efforts to intervene will need to be both “bottom/local up” and “top/national/international down.”  Developing practical, sustainable and effective solutions requires a keen understanding of local socio-economic factors and a solid grasp of complex national and regional health and environmental policies. Efforts should begin within each country by developing strategies by the Ministries of Health, Agriculture and Wildlife to work together in common databases and emerging issues. In turn, federal agencies should rely on local scientists who are intimately familiar with these complicated, on-the-ground realities. Consistent with this philosophy and goals, we need to strive to ensure lasting local conservation impacts with global health solutions with every project by training community leaders, volunteers and school children, in addition to professional, in-country experts. Conservation Medicine and One Health offer time-sensitive opportunities to the conservation, veterinary and public health community to reach out for new collaborations with simultaneous benefits for humans, animals, plants and the environment.